Background: Several studies have
suggested that the serotonin receptor 1B gene (5HT1B) may be important in the pathogenesis of alcohol dependence
(alcoholism; ALC; AD). We examined whether 5HT1B gene A-161T polymorphisms (rs130058) are a susceptibility factor for
total AD and subgroups of AD. We further explored correlation of this 5HT1B gene variant between anxiety–depression alcoholism (ANX/DEP
ALC) and antisocial alcoholism (antisocial ALC) subgroups because of the high
comorbidity of anxiety–depression, antisocial personality disorder, and AD.
Methods: We recruited 522 Han Chinese
in Taiwan for this study: 322 AD patients and 200 controls. The patient group
was recruited primarily from medical teaching hospitals; patients with
antisocial alcoholism were recruited from Taiwanese prisons. Individuals with AD
were classified into 3 homogeneous clinical subgroups—pure alcoholism (pure
ALC), ANX/DEP ALC, and antisocial ALC—using DSM-IV diagnosis. The 5HT1B gene A-161T polymorphism was
determined using PCR–RFLP.
Results: No significant differences
in genotypic and allelic frequencies were found between controls and the total
AD group or between controls and the 3 AD subgroups. However, there were
significant differences in the 5HT1B
gene A-161T polymorphism at both the genotype and allelic
levels between the ANX/DEP ALC and antisocial ALC subgroups.